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Indication

NGENLA is a prescription medicine that contains a form of human growth hormone, like the growth hormone made by the human body, for children 3 years of age and older who are not growing because of low or no growth hormone levels.

How to use NGENLA
Key steps to inject
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1

Get ready

  • Wash and dry your hands

  • You can use the pen straight from the refrigerator. For a more comfortable injection, leave it at room temperature for up to 30 minutes

  • Check the expiration date on the pen label. Do not use if the expiration date has passed

  • Your child’s healthcare provider will show you how to inject NGENLA before it is used for the first time. Do not try to inject NGENLA until you have been shown the right way by your child’s healthcare provider.

For dosing reminders, text MYNGENLA to 46286

By entering your mobile phone number above you consent to receive marketing and/or non-marketing texts from Pfizer and/or Engaged Media with information regarding the NGENLA Text Reminder Program at the phone number you provided. You understand that providing this consent is not required or a condition of purchasing any products or services. Message frequency varies. Message and data rates may apply. Complete terms can be found at https://engagedrx.com/pghd/. Text HELP to 46286 for info, Text STOP to 46286 to opt out.

2

Choose and clean your injection site

  • Injection should be given in the abdomen, front of the upper thighs, buttocks, or rear of the upper arms

  • If more than 1 injection is needed to complete your full dose, each injection should be given in a different injection site 

  • Do not inject into bony areas; areas that are bruised, red, sore, or hard; or areas that have scars or skin conditions

  • Clean the injection site with an alcohol swab and let dry

  • Do not touch injection site after cleaning

For dosing reminders, text MYNGENLA to 46286

By entering your mobile phone number above you consent to receive marketing and/or non-marketing texts from Pfizer and/or Engaged Media with information regarding the NGENLA Text Reminder Program at the phone number you provided. You understand that providing this consent is not required or a condition of purchasing any products or services. Message frequency varies. Message and data rates may apply. Complete terms can be found at https://engagedrx.com/pghd/. Text HELP to 46286 for info, Text STOP to 46286 to opt out.

3

Check medicine and prepare your injection

  • Pull off the pen cap and set it aside for after the injection. Check the medicine's color. It should be clear to slightly yellow and free of flakes or particles. Do not inject if medicine is cloudy, dark yellow, or has flakes or particles

  • Take a new needle and pull off its protective paper. Attach a new needle for each injection

  • Pull off the outer needle cover. Set it aside for later to help remove the needle

  • Pull off the inner needle cap. Throw it away in a sharps container

For dosing reminders, text MYNGENLA to 46286

By entering your mobile phone number above you consent to receive marketing and/or non-marketing texts from Pfizer and/or Engaged Media with information regarding the NGENLA Text Reminder Program at the phone number you provided. You understand that providing this consent is not required or a condition of purchasing any products or services. Message frequency varies. Message and data rates may apply. Complete terms can be found at https://engagedrx.com/pghd/. Text HELP to 46286 for info, Text STOP to 46286 to opt out.

4

Prime a new pen

If this is your first time using your NGENLA pen, follow these steps to remove air bubbles and make sure you set the correct dose. You can skip these steps if you have already set up your pen.

  • Turn and set the dose knob to 0.4 for the 24-mg pen; set the dose knob to 1.0 for the 60-mg pen

  • Hold the pen with the needle pointing up. Tap cartridge holder gently to float any air bubbles to the top

  • Press the injection button until it cannot go any further and you see “0” in the dose window. If liquid appears at the needle tip, the pen is set up 

  • If liquid has not appeared, repeat these steps. If liquid does not appear after repeating these steps 5 times, attach a new needle and try 1 more time. Do not use the pen if liquid still does not appear

For dosing reminders, text MYNGENLA to 46286

By entering your mobile phone number above you consent to receive marketing and/or non-marketing texts from Pfizer and/or Engaged Media with information regarding the NGENLA Text Reminder Program at the phone number you provided. You understand that providing this consent is not required or a condition of purchasing any products or services. Message frequency varies. Message and data rates may apply. Complete terms can be found at https://engagedrx.com/pghd/. Text HELP to 46286 for info, Text STOP to 46286 to opt out.

5

Set your prescribed dose

  • Turn the knob to set your dose; dose knob turns 0.2 mg at a time for the NGENLA 24-mg pen and 0.5 mg at a time for the NGENLA 60-mg pen

  • Check the dose window to make sure you have set the correct dose. Important: Do not press the injection button while setting your dose 

  • If your dose is more than 30 mg when using the NGENLA 60-mg pen, or more than 12 mg when using the NGENLA 24-mg pen, you will need more than 1 injection. Only split your dose if you have been trained or advised by your health care provider on how to do this. Use a new needle for each injection

For dosing reminders, text MYNGENLA to 46286

By entering your mobile phone number above you consent to receive marketing and/or non-marketing texts from Pfizer and/or Engaged Media with information regarding the NGENLA Text Reminder Program at the phone number you provided. You understand that providing this consent is not required or a condition of purchasing any products or services. Message frequency varies. Message and data rates may apply. Complete terms can be found at https://engagedrx.com/pghd/. Text HELP to 46286 for info, Text STOP to 46286 to opt out.

6

Inject your dose

  • Hold the pen so you can see the numbers in the dose window

  • Insert the needle straight into the skin at a 90-degree angle

  • Press the injection button until it can’t go down any further and “0” is shown in the dose window. Continue to press the injection button while counting to 10. Counting to 10 will allow the full dose of medicine to be given

  • After counting to 10, let go of the injection button and remove the pen from the injection site by pulling the needle straight out

  • Be sure to rotate the injection site each week

For dosing reminders, text MYNGENLA to 46286

By entering your mobile phone number above you consent to receive marketing and/or non-marketing texts from Pfizer and/or Engaged Media with information regarding the NGENLA Text Reminder Program at the phone number you provided. You understand that providing this consent is not required or a condition of purchasing any products or services. Message frequency varies. Message and data rates may apply. Complete terms can be found at https://engagedrx.com/pghd/. Text HELP to 46286 for info, Text STOP to 46286 to opt out.

7

Finish up

  • Carefully place the outer needle cover back on the needle. Press on the outer needle cover until it is secure

  • Unscrew the capped needle from the pen, and gently pull until the capped needle comes off

  • Dispose of the capped needle in a sharps container. Do not reuse needles

  • Replace the pen cap. If there is any medicine left, store it in the refrigerator between uses

For dosing reminders, text MYNGENLA to 46286

By entering your mobile phone number above you consent to receive marketing and/or non-marketing texts from Pfizer and/or Engaged Media with information regarding the NGENLA Text Reminder Program at the phone number you provided. You understand that providing this consent is not required or a condition of purchasing any products or services. Message frequency varies. Message and data rates may apply. Complete terms can be found at https://engagedrx.com/pghd/. Text HELP to 46286 for info, Text STOP to 46286 to opt out.

Read the full Instructions for Use for complete administration steps, including additional steps for the first-time use of a new pen, or refer to the How to Use NGENLA Placemat.

Never miss an injection!

For dosing reminders, 
text MYNGENLA to 46286

By entering your mobile phone number above you consent to receive marketing and/or non-marketing texts from Pfizer and/or EngagedMedia with information regarding the NGENLA Text Reminder Program at the phone number you provided. You understand that providing this consent is not required or a condition of purchasing any products or services. Message frequency varies. Message and data rates may apply. Complete terms can be found at https://engagedrx.com/pghd/. Text HELP to 46286 for info, Text STOP to 46286 to opt out.

Important Safety Information & Use

Important Safety
Information & Use

INDICATION
NGENLA is a prescription medicine that contains a form of human growth hormone, like the growth hormone made by the human body, for children 3 years of age and older who are not growing because of low or no growth hormone levels.
IMPORTANT SAFETY INFORMATION
Do not use NGENLA if:
  • your child has a critical illness caused by certain types of heart or stomach surgery, trauma or breathing problems.
  • your child is allergic to somatrogon-ghla or any of the ingredients in NGENLA.
  • your child has closed bone growth plates.
  • your child has cancer or other tumors.
  • your child’s healthcare provider tells you that your child has certain types of eye problems caused by diabetes.
  • your child has Prader-Willi syndrome, is severely obese, or has breathing problems including sleep apnea (briefly stopping breathing during sleep).
Before using NGENLA, tell your child’s healthcare provider about all of your child’s medical conditions, including if your child:
  • has had heart or stomach surgery, trauma or serious breathing (respiratory) problems.
  • has had a history of problems breathing while they slept.
  • has or has had cancer or any tumor.
  • has diabetes.
  • is pregnant or plans to become pregnant. It is not known if NGENLA will harm your child’s unborn baby. Talk to your child’s healthcare provider if your child is pregnant or plans to become pregnant.
  • is breastfeeding or plans to breastfeed. It is not known if NGENLA passes into breast milk. You and your child’s healthcare provider should decide if they will take NGENLA while breastfeeding.
Tell your child’s healthcare provider about all the medicines your child takes, including prescription and over-the-counter medicines, vitamins, and herbal supplements. NGENLA may affect how other medicines work, and other medicines may affect how NGENLA works.

NGENLA may cause serious side effects, including:
  • high risk of death in people who have critical illnesses because of heart or stomach surgery, trauma or serious breathing (respiratory) problems.
  • serious allergic reactions. Get medical help right away if your child has the following symptoms: swelling of the face, lips, mouth, or tongue, trouble breathing, wheezing, severe itching, skin rashes, redness, or swelling, dizziness or fainting, fast heartbeat or pounding in the chest, sweating.
  • increased risk of growth of cancer or a tumor that is already present and increased risk of the return of cancer or a tumor in people who were treated with radiation to the brain or head as children and who developed low growth hormone problems. Your child’s healthcare provider will need to monitor your child for a return of cancer or a tumor. Contact your child’s healthcare provider if your child starts to have headaches, or has changes in behavior, changes in vision, or changes in moles, birthmarks, or the color of the skin.
  • new or worsening high blood sugar or diabetes. Your child’s blood sugar may need to be monitored during treatment with NGENLA.
  • increase in pressure inside the skull. If your child has headaches, eye problems, nausea or vomiting, contact your child’s healthcare provider.
  • your child’s body holding too much fluid (fluid retention) such as swelling in the hands and feet, pain in the joints or muscles or nerve problems that cause pain, burning or tingling in the hands, arms, legs and feet. Fluid retention can happen in children during treatment with NGENLA. Tell your child’s healthcare provider if your child has any of these signs or symptoms of fluid retention.
  • decrease in a hormone called cortisol. Your child’s healthcare provider will do blood tests to check your child’s cortisol levels. Tell your child’s healthcare provider if your child has severe fatigue, dizziness, weakness, vomiting, dehydration, or weight loss.
  • decrease in thyroid hormone levels. Decreased thyroid hormone levels may affect how well NGENLA works. Your child’s healthcare provider will do blood tests to check your child’s hormone levels.
  • hip and knee pain or limp (slipped capital femoral epiphysis). This may lead to a serious condition where bone tissue dies due to a lack of blood supply (osteonecrosis). Get medical help for your child right away if your child develops a limp or has hip or knee pain.
  • worsening of curvature of the spine (scoliosis). If your child has scoliosis, your child will need to be checked often for an increase in the curve of the spine.
  • severe and constant stomach (abdominal) pain. This could be a sign of pancreatitis. Tell your child’s healthcare provider if your child has any new abdominal pain.
  • loss of fat and tissue weakness in the area of skin you inject. Talk to your child’s healthcare provider about rotating the areas where you inject NGENLA.
  • high risk of sudden death in children with Prader-Willi syndrome who are severely obese or have breathing problems, including sleep apnea.
  • increase in phosphorus, alkaline phosphatase and parathyroid hormone levels in the blood. Your child’s healthcare provider will do blood tests to check this.
The most common side effects (≥5%) of NGENLA include: injection site reactions (such as pain, swelling, rash, itching, bleeding), common cold, headache, fever, low red blood cells (anemia), cough, vomiting, decrease in thyroid hormone levels, stomach (abdominal) pain, rash, throat pain.

This site is intended only for U.S. residents. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only and is not intended to replace discussions with a healthcare provider.

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