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Indication

NGENLA is a prescription product for the treatment of growth failure in children 3 years of age and older who do not make enough growth hormone on their own. This condition is called growth hormone deficiency (GHD).

How to use NGENLA
Key steps to inject
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1

Get ready

  • Wash and dry your hands

  • You can use the pen straight from the refrigerator. For a more comfortable injection, leave it at room temperature for up to 30 minutes

  • Check the expiration date on the pen label. Do not use if the expiration date has passed

For dosing reminders, text MYNGENLA to 46286

View mobile Terms and Conditions at engagedrx.com/pghd. Msg & Data rates may apply. Msg frequency varies. Text HELP for info, STOP to opt out. Pfizer’s Privacy Policy can be found at pfizer.com/privacy.

2

Choose and clean your injection site

  • Injection should be given in the abdomen, front of the upper thighs, buttocks, or rear of the upper arms

  • If more than 1 injection is needed to complete your full dose, each injection should be given in a different injection site 

  • Do not inject into bony areas; areas that are bruised, red, sore, or hard; or areas that have scars or skin conditions

  • Clean the injection site with an alcohol swab and let dry

  • Do not touch injection site after cleaning

For dosing reminders, text MYNGENLA to 46286

View mobile Terms and Conditions at engagedrx.com/pghd. Msg & Data rates may apply. Msg frequency varies. Text HELP for info, STOP to opt out. Pfizer’s Privacy Policy can be found at pfizer.com/privacy.

3

Check medicine and prepare your injection

  • Pull off the pen cap and set it aside for after the injection. Check the medicine's color. It should be clear to slightly yellow and free of flakes or particles. Do not inject if medicine is cloudy, dark yellow, or has flakes or particles

  • Take a new needle and pull off its protective paper. Attach a new needle for each injection

  • Pull off the outer needle cover. Set it aside for later to help remove the needle

  • Pull off the inner needle cap. Throw it away in a sharps container

For dosing reminders, text MYNGENLA to 46286

View mobile Terms and Conditions at engagedrx.com/pghd. Msg & Data rates may apply. Msg frequency varies. Text HELP for info, STOP to opt out. Pfizer’s Privacy Policy can be found at pfizer.com/privacy.

4

Prime a new pen

If this is your first time using your NGENLA pen, follow these steps to remove air bubbles and make sure you set the correct dose. You can skip these steps if you have already set up your pen.

  • Turn and set the dose knob to 0.4 for the 24-mg pen; set the dose knob to 1.0 for the 60-mg pen

  • Hold the pen with the needle pointing up. Tap cartridge holder gently to float any air bubbles to the top

  • Press the injection button until it cannot go any further and you see “0” in the dose window. If liquid appears at the needle tip, the pen is set up 

  • If liquid has not appeared, repeat these steps. If liquid does not appear after repeating these steps 5 times, attach a new needle and try 1 more time. Do not use the pen if liquid still does not appear

For dosing reminders, text MYNGENLA to 46286

View mobile Terms and Conditions at engagedrx.com/pghd. Msg & Data rates may apply. Msg frequency varies. Text HELP for info, STOP to opt out. Pfizer’s Privacy Policy can be found at pfizer.com/privacy.

5

Set your prescribed dose

  • Turn the knob to set your dose; dose knob turns 0.2 mg at a time for the NGENLA 24-mg pen and 0.5 mg at a time for the NGENLA 60-mg pen

  • Check the dose window to make sure you have set the correct dose. Important: Do not press the injection button while setting your dose 

  • If your dose is more than 30 mg when using the NGENLA 60-mg pen, or more than 12 mg when using the NGENLA 24-mg pen, you will need more than 1 injection. Only split your dose if you have been trained or advised by your health care provider on how to do this. Use a new needle for each injection

For dosing reminders, text MYNGENLA to 46286

View mobile Terms and Conditions at engagedrx.com/pghd. Msg & Data rates may apply. Msg frequency varies. Text HELP for info, STOP to opt out. Pfizer’s Privacy Policy can be found at pfizer.com/privacy.

6

Inject your dose

  • Hold the pen so you can see the numbers in the dose window

  • Insert the needle straight into the skin at a 90-degree angle

  • Press the injection button until it can’t go down any further and “0” is shown in the dose window. Continue to press the injection button while counting to 10. Counting to 10 will allow the full dose of medicine to be given

  • After counting to 10, let go of the injection button and remove the pen from the injection site by pulling the needle straight out

  • Be sure to rotate the injection site each week

For dosing reminders, text MYNGENLA to 46286

View mobile Terms and Conditions at engagedrx.com/pghd. Msg & Data rates may apply. Msg frequency varies. Text HELP for info, STOP to opt out. Pfizer’s Privacy Policy can be found at pfizer.com/privacy.

7

Finish up

  • Carefully place the outer needle cover back on the needle. Press on the outer needle cover until it is secure

  • Unscrew the capped needle from the pen, and gently pull until the capped needle comes off

  • Dispose of the capped needle in a sharps container. Do not reuse needles

  • Replace the pen cap. If there is any medicine left, store it in the refrigerator between uses

For dosing reminders, text MYNGENLA to 46286

View mobile Terms and Conditions at engagedrx.com/pghd. Msg & Data rates may apply. Msg frequency varies. Text HELP for info, STOP to opt out. Pfizer’s Privacy Policy can be found at pfizer.com/privacy.

Read the full Instructions for Use for complete administration steps, including additional steps for the first-time use of a new pen, or refer to the How to Use NGENLA Placemat.

Never miss an injection!

For dosing reminders, 
text MYNGENLA to 46286

View mobile Terms and Conditions at engagedrx.com/pghd. Msg & Data rates may apply. Msg frequency varies. Text HELP for info, STOP to opt out. Pfizer’s Privacy Policy can be found at pfizer.com/privacy.

Important Safety Information & Use

INDICATION
NGENLA is a prescription product for the treatment of growth failure in children 3 years of age and older who do not make enough growth hormone on their own. This condition is called growth hormone deficiency (GHD).   
IMPORTANT SAFETY INFORMATION
  • Growth hormone should not be used in children after the growth plates have closed.
  • Growth hormone should not be used in children with some types of eye problems
    caused by diabetes (diabetic retinopathy).
  • Growth hormone should not be used in children who have cancer or other tumors.
  • Growth hormone should not be used in children who are critically ill because of some
    types of heart or stomach surgery, trauma, or breathing (respiratory) problems.
  • Growth hormone should not be used in children with Prader-Willi syndrome who are
    very overweight or have breathing problems including sleep apnea.
  • NGENLA should not be used by children who have had an allergic reaction to
    somatrogon-ghla or any of the ingredients in NGENLA. Look for prompt medical
    attention in case of an allergic reaction.
  • Some children have developed diabetes mellitus while taking growth hormone. Dosages
    of diabetes medicines may need to be adjusted during treatment with NGENLA.
    Children should be watched carefully if NGENLA is given along with glucocorticoid
    therapy and/or other drugs that are processed by the body in the same way.
  • In childhood cancer survivors, treatment with growth hormone may raise the likelihood
    of a new tumor, particularly some benign (non-cancerous) brain tumors. This likelihood
    may be higher in children who were treated with radiation to the brain or head. Your
    child’s health care provider will need to check your child for a return of cancer or a
    tumor.
  • Children treated with growth hormone have had increased pressure in the brain. If your
    child has headaches, eye problems, nausea (feeling like you are going to be sick), or
    vomiting, contact your child’s health care provider.
  • NGENLA may decrease thyroid hormone levels. Decreased thyroid hormone levels may
    change how well NGENLA works. Your child’s health care provider will do blood tests to
    check your child’s hormone levels.
  • Children treated with growth hormone should be checked regularly for low serum
    cortisol levels and/or the need to increase the dose of the glucocorticoids they are
    taking.
  • In children experiencing fast growth, curvature of the spine may develop or worsen. This
    is also called scoliosis. Children with scoliosis should be checked regularly to make sure
    their scoliosis does not get worse during their growth hormone therapy.
  • Use a different area on the body for each injection. This can help to avoid skin problems
    such as lumpiness or soreness.
  • Growth hormone treatment may cause serious and constant stomach (abdominal) pain.
    This could be a sign of pancreatitis. Tell your child’s health care provider if your child has
    any new stomach (abdominal) pain.
  • In studies of NGENLA in children with GHD, side effects included injection site reactions
    such as pain, swelling, rash, itching, or bleeding. Other side effects were the common
    cold, headache, fever (high temperature), low red blood cells (anemia), cough, vomiting,
    decreased thyroid hormone levels, stomach pain, rash, or throat pain.
  • A health care provider will help you with the first injection. He or she will also train you
    on how to inject NGENLA.
  • Rx only

This site is intended only for U.S. residents. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only and is not intended to replace discussions with a healthcare provider.

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